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Juvenile Rheumatoid Arthritis and Physical Activity
Hanková, Kristýna ; Hronzová, Marie (advisor) ; Hájková, Jana (referee)
Bachelor thesis discusses the issue of juvenile idiopathic arthritis (JIA). It deals specifically with principles, selection and application of appropriate physical activities that are a significant part of the overall treatment of patients affected by JIA. The theoretical part focuses on basic terms and the summarization of findings about JIA; it further deals with causing factors, clinical manifestation, diagnosis and treatment options. The purpose and importance of physical therapy is described is the special part. For each stage of the disease appropriate set of exercises and principles of movements for individual human body joints are presented, with more options of physical activities suitable for a complex physical treatment. The practical part then presents a case study of an individual with juvenile idiopathic arthritis who has undergone a kinesiological examination which was a basis for creating a short-term and a long-term exercise plan.
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Epidemiological aspects of inflammatory rheumatic diseases and diffusional diseases of binding tissue.
Hánová, Petra ; Pavelka, Karel (advisor) ; Bencko, Vladimír (referee) ; Horák, Pavel (referee)
v anglickém jazyce Introduction: No information was known about frequency of common inflammatory disorders in rheumatology in the Czech Republic. Aims of the study: To estimate the standardized annual incidence (INC) and point prevalence (PREV) of six diseases (rheumatoid arthritis-RA, juvenile idiopathic arthritis-JIA, gout, psoriatic arthritis-PsA, ankylosing spondylitis-AS, reactive arthritis-ReA) in a population-based study in two regions of the Czech Republic (CR). Methods: INC: Incident cases were registered on condition that the definite diagnosis was confirmed according to existing classification criteria during the study period. PREV was studied on the basis of identification of established diagnoses at a time point. Crude rates were standardized for age and sex. Results: Both INC and PREV are shown per 100.000 inhabitants. RA INC:31 (95%CI 20-42), PREV:610 (95%CI 561-658). Gout-INC:41 (95%CI 28-53), PREV:300 (95% CI 266-334). JIA-INC: 13 (95% CI 1-20), PREV:140 (95%CI 117-280). PsA-INC:3,6 (95% CI 1-8), PREV:49 (95%CI 40-60). AS-INC:6 (95% CI 3-11), PREV:94 (95% CI 94-109). ReA-INC:9 (95% CI 6-15), PREV:91 (95% CI 78-106). Conclusion: This is the first population-based study estimating annual incidence and prevalence rates of the most common rheumatological disorders in the Czech...
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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The role of miR-150 in the physiopathology of oligoarticular juvenile idiopathic arthritis
Diviš, Daniel ; Pávek, Petr (advisor) ; Soukup, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Daniel Diviš Supervisors: Prof. Dr. Florence Apparailly, Directrice de Recherche Prof. PharmDr. Petr Pávek, Ph.D. (formal tutor) Title of diploma thesis: The role of miR-150 in the physiopathology of oligoarticular juvenile idiopathic arthritis Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatoid disease affecting children, and its pathological mechanisms are still poorly understood. Innate and adaptive immunity including myeloid cells play a major role in these processes. Epigenetic deregulations along with non-coding microRNAs have been reported in many inflammatory diseases. Moreover, preliminary results obtained by the research group of Prof. Florence Apparailly showed accumulation of intermediate monocytes along with the high expression of miR-150 in the synovial fluid of children affected by oligoarticular JIA. Based on these findings a hypothesis has been postulated suggesting that miR-150 could have a role in the pathogenesis of this disease and in the regulation of monocyte differentiation and function. To study the impact of miR-150 on monocytes from the peripheral blood of healthy donors, transfection experiments were performed to neutralize miR-150. The...
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The role of miR-150 in the physiopathology of oligoarticular juvenile idiopathic arthritis
Diviš, Daniel ; Pávek, Petr (advisor) ; Soukup, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Daniel Diviš Supervisors: Prof. Dr. Florence Apparailly, Directrice de Recherche Prof. PharmDr. Petr Pávek, Ph.D. (formal tutor) Title of diploma thesis: The role of miR-150 in the physiopathology of oligoarticular juvenile idiopathic arthritis Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatoid disease affecting children, and its pathological mechanisms are still poorly understood. Innate and adaptive immunity including myeloid cells play a major role in these processes. Epigenetic deregulations along with non-coding microRNAs have been reported in many inflammatory diseases. Moreover, preliminary results obtained by the research group of Prof. Florence Apparailly showed accumulation of intermediate monocytes along with the high expression of miR-150 in the synovial fluid of children affected by oligoarticular JIA. Based on these findings a hypothesis has been postulated suggesting that miR-150 could have a role in the pathogenesis of this disease and in the regulation of monocyte differentiation and function. To study the impact of miR-150 on monocytes from the peripheral blood of healthy donors, transfection experiments were performed to neutralize miR-150. The...
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A case of physiotherapeutic care of patient with juvenile idiopathic arthritis
Hejtmánková, Veronika ; Kučerová, Ilona (advisor) ; Zinková, Iva (referee)
Title: A case of physiotherapeutic care of patient with juvenile idiopathic arthritis Objectives: The major aim of this bacheor thesis is to highlight the role of physiotherapist in the diagnosis and therapy of juvenile idiopathic arthritis and to verify the effect of physiotherapeutic care chosen by the investigator in the therapy of the patient with this disease. Methods: This bachelor thesis was made as a part of continuos professional practise in the Institut of Rheumatology in Prague, which was in the period from 7. 1. 2019 to 1. 2. 2019 led by the head of the physiotherapy department Eva Taušová. The thesis is divided into two main parts. The first part, the general part contains theoretical informations about disease called juvenile idiopathic arthritis, its characteristic, description of its clinical symptoms, its diagnostics and its treatment options. The second part, special part contains detailed case of physiotherapeutic care of the patient with juvenile idiopathic arthritis. Results: A part of the special part is control kinesiological analysis, which demonstrates improvement in patient's clinical status. Keywords: juvenile idiopathic arthritis, JIA, rheumatology, physiotherapy
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Nursing care of child with juvenilie idiopathic arthritis
Bobitko, Julia ; Jeřábková, Lenka (advisor) ; Kulhavá, Miluše (referee)
Juvenile idiopathic arthritis is one of the most common rheumatic diseases that affects children less than 16 years of age. The illness is considered irrecoverable because of its unclear aetiology. My work is focused on nursing care of a child with juvenile idiopathic arthritis due to the very low awarness of this disease. The main objective was to describe the nursing care of a child with a given disease and to increase awareness of juvenile idiopathic arthritis. Another objective was to create information material for the public about the illness. I choose a case study method to meet these goals. I described the nursing process of the patient with the disease in the practical part of the bachelor thesis, supplemented by Mary Henderson model. Information was drew mainly from medical records, interviews with parents, medical staff, and by providing nursing care to the chosen patient. The specifics of nursing care of a child with juvenile idiopathic arthritis were described on the basis of the information and knowledge gained during the hospitalization of the patient. These informations were used also for creation the information material for the general public. keywords: juvenile idiopathic arthritis, nursing care, rheumatology, paediatrics nursing, arthritis
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Epidemiological aspects of inflammatory rheumatic diseases and diffusional diseases of binding tissue.
Hánová, Petra ; Pavelka, Karel (advisor) ; Bencko, Vladimír (referee) ; Horák, Pavel (referee)
v anglickém jazyce Introduction: No information was known about frequency of common inflammatory disorders in rheumatology in the Czech Republic. Aims of the study: To estimate the standardized annual incidence (INC) and point prevalence (PREV) of six diseases (rheumatoid arthritis-RA, juvenile idiopathic arthritis-JIA, gout, psoriatic arthritis-PsA, ankylosing spondylitis-AS, reactive arthritis-ReA) in a population-based study in two regions of the Czech Republic (CR). Methods: INC: Incident cases were registered on condition that the definite diagnosis was confirmed according to existing classification criteria during the study period. PREV was studied on the basis of identification of established diagnoses at a time point. Crude rates were standardized for age and sex. Results: Both INC and PREV are shown per 100.000 inhabitants. RA INC:31 (95%CI 20-42), PREV:610 (95%CI 561-658). Gout-INC:41 (95%CI 28-53), PREV:300 (95% CI 266-334). JIA-INC: 13 (95% CI 1-20), PREV:140 (95%CI 117-280). PsA-INC:3,6 (95% CI 1-8), PREV:49 (95%CI 40-60). AS-INC:6 (95% CI 3-11), PREV:94 (95% CI 94-109). ReA-INC:9 (95% CI 6-15), PREV:91 (95% CI 78-106). Conclusion: This is the first population-based study estimating annual incidence and prevalence rates of the most common rheumatological disorders in the Czech...
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Therapeutic rehabilitation in patients with juvenile idiopathic arthritis
Helebrantová, Soňa ; Zounková, Irena (advisor) ; Smolíková, Libuše (referee)
The juvenile idiopathic arthritis disease (JIA) is the most common chronic rheumatic disease in childhood and a significant cause of acquired disability in children and adolescents. Patients suffer from acute and chronic pain, reduced mobility, and stiffness in the joints, which leads to a limitation in physical activity. The bachelor thesis includes the latest information about JIA in connection with therapeutic rehabilitation- physiotherapy. It deals with the effect of the disease on the function of the musculoskeletal system, and the ways in which therapeutic rehabilitation can effect already developed disorders. The thesis consists of two sections. The first part is theoretical and includes information from the literature, with focus on information that has been published in Czech and foreign literature over the last 10 years. The second part is devoted to case report of a patient with JIA, including an examination, a course of rehabilitation and its effects on overall health. In the therapy there were used questionnaires about physical activity, such as C-HAQ, methods based on developmental kinesiology or kinesiotaping. The main benefit of the thesis is the analysis of all available therapeutic methods in patients with JIA. The emphasis is placed on medical rehabilitation - physiotherapy,...
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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